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New Avenues for Birth Control Pill for Men

17 August 2012

In that perennial quest for the holy grail, the pill for men, scientists are showing a new round of optimism.  Every attempt in recent years has failed due to a host of complications with terminating billions of sperm effectively and without side effect.  Organon’s attempt at an implant failed in trials, for example, despite it being heralded as some kind of messiah-pharmaceutical.  Nevertheless, some new drugs are in testing phase, however, pursuing the prospect of massive sums of money to the winning developers.

James Bradner reports for his squad, which has seen successful results among mice.  The drug JQ1 targets a testis-specific protein, rendering production of sperm impossible.  Bradner reports elsewhere that he suspects the pill for men will be available within a decade.

Indian scientists have developed a gel called RISUG which is injected into the vas deferens in a procedure much like a vasectomy.  The chemical somehow disrupts sperm by electrocuting them with a charge produced by the surface of the polymer.  It is in phase III trials in India as of 2012.

Testosterone undecanoate, currently used with success for hypogonadism, is being considered as a contraceptive.  Chinese researchers report early success in trials with their injection method, which mixes the compound in tea seed oil.  Some permanent infertility was noted, however.

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